| 1948 | Abandoned army camp converted to military hospital (Army Hospital No. 5) under Israeli leadership of Dr. Chaim Sheba, Surgeon General, Israel Defense Forces. |
| 1953 | Administration of 650-bed hospital transferred to Ministry of Health, becoming a civilian medical center. |
| 1959 | Rehabilitation Center established. |
| 1960 | First open-heart surgery performed. |
| 1964 | Artificial Kidney Unit established. |
| 1968 | Fellowship program instituted for students from the United States. |
| 1970 | Guardians of Courage established in Los Angeles by Charlotte Sinay. |
| 1979 | Oncology Building dedicated. |
| 1981 | Gindi Family Cafeteria, in memory of Elie J. Gindi of Los Angeles, completed. |
| 1982 | First Israeli test tube baby born. |
| 1983 | 25-bed hospice program instituted for terminally ill. |
| 1984 | Max & Pauline Zimmer Foundation funded Cardiac Outpatient Clinic. |
| 1985 | Friends of Sheba Open Heart Surgery Department inaugurated. Samuel Jared Kushnick Pediatric Immunology Research Center established. |
| 1986 | The Lodzer Organization of California established Leukemia Project in memory of Rita Miller. |
| 1987 | Friends of Sheba Women's Group established to benefit Pediatric Psychiatric Center. |
| 1988 | Friends of Sheba contributed $850,000 to Sheba Cancer Institute. |
| 1990 | Friends of Sheba launched $1.5 million campaign for Obstetrics/Gynecology project. |
| 1991 | Marilyn & Sigi Ziering funded Department of Obstetrics/Gynecology project. |
| 1992 | Elizabeth Taylor AIDS Research Institute established. |
| 1993 | Frances Brody Gynecological Clinic established. |
| 1995 | Israel's first AIDS Hospice created. Seymour Hammerman Pediatric Psychosomatic Department established (inspired by Stanley Eisenberg and Marjorie Pressman). |
| 1996 | Anna & Max Webb Oncological Day Clinic inaugurated by the Webbs. |
| 1997 | Hospital selected by GE as one of 15 in the world to use revolutionary Magnetic Resonance Technology to make both diagnosis and non-invasive surgery safer and more accurate. |
| 1998 | Women's Group & Sponsor-a-Child Campaign donated $70,000 to special pediatric nurses training program. Women of Sheba sent $125,000 to Hospital for first Pediatric Hospice in Israel, the Marion and Elie Wiesel Children's Pavilion. Center for Adolescents & Young Adults established by Ruth Ziegler & Ziegler Family Trust. |
| 1999 | Friends of Sheba donated $250,000 to purchase a gamma camera for use in non-invasive surgery. Friends of Sheba donated an additional $100,000 towards the Anna & Max Webb Oncology Day Clinic. |
| 2000 | Women of Sheba donated $100,000 to the Pediatric Gastroenterology Department. Friends of Sheba donated an additional $150,000 to the hospital. |
| 2001 | Friends of Sheba launched $1 million campaign to establish the Dr. Sigi Ziering Brain Tumor Unit at the new Oncology Institute. |
| 2002 | Hospital created Medical Simulation Center to train Israel's IDF doctors, nurses, and paramedics for disaster attacks. Hospital performed first stem cell transplant in Israel. Friends of Sheba donated over $600,000 to the hospital. |
| 2003 | Rubinfeld Rehabilitation Hotel donated by Rubin Rubinfeld and Family. Dr. Sigi Ziering Brain Tumor Unit at new Oncology Institute completed. |
| 2004 | Dr. Sigi Ziering Brain Tumor Unit dedicated. Shani-Goldman Building inaugurated. |
| 2005 | Friends of Sheba launched its first Mission to Israel, led by Executive Director Jack Saltzberg and Co-Chairs Gal Ben-Naim and Ruth Steinberger. Four-year campaign announced: the Israel Center for Newborn Screening, 2006-2009, chaired by Marilyn Ziering. |
| 2006 | February: Anna & Max Webb donated $2 million toward the Israel Center for Newborn Screening, the largest gift ever in the history of the Friends of Sheba Medical Center. May: A group of supporters led by Daniel Ziv pledged over $250,000 to purchase new life-saving equipment in the pediatric intensive care unit equipment in The Edmond and Lily Safra Children's Hospital. May: Prime Minister Ariel Sharon, in a coma following a stroke, is moved to Sheba Medical Center. July: The most severely wounded soldiers and civilians from the war in Lebanon are treated at Sheba and the National Center for Rehabilitation. November: Marilyn Ziering pledged $4 million toward a naming gift for the new Sigi & Marilyn Ziering National Center for Newborn Screening. |
| 2007 | January: Marilyn Ziering created the Million Dollar Women's Club, with a goal of one hundred women raising one million dollars. February: Dr. Amitai Ziv, Sheba's Deputy Director, was awarded the $100,000 Charles Bronfman Humanitarian Award for "Changing the Face of Medical Education and reshaping the way medical care is delivered throughout the world." |
